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Global Molecular Cytogenetics Market $4.7 Billion by 2027

The global market for molecular cytogenetics expected to reach $4.7 billion by 2027, growing steadily at a CAGR of 11.5% over the forecast period, driven by increasing prevalence of cancer, shorter turnaround time, cost-effectiveness, high specificity, and rapid update of novel diagnostic technologies.

Global Molecular Cytogenetics Market

The field of cytogenetics has focused on studying the number, structure, function and origin of chromosomal abnormalities and the evolution of chromosomes. The development of fluorescent molecules that either directly or via an intermediate molecule bind to DNA has led to the development of fluorescent in situ hybridization (FISH), a technology linking cytogenetics to molecular genetics.

  • This technique has a wide range of applications that increased the dimension of chromosome analysis. The field of cytogenetics is particularly important for medical diagnostics and research as well as for gene ordering and mapping.
    • Furthermore, the increased application of molecular biology techniques, such as array-based technologies, has led to improved resolution, extending the recognized range of microdeletion/microduplication syndromes and genomic disorders.
  • In adopting these newly expanded methods, cytogeneticists have used a range of technologies to study the association between visible chromosome rearrangements and defects at the single nucleotide level.
    • Overall, molecular cytogenetic techniques offer a remarkable number of potential applications, ranging from physical mapping to clinical and evolutionary studies, making a powerful and informative complement to other molecular and genomic approaches.

Traditional cytogenetic methods have relied on tissue culture techniques to generate adequate mitotic cells for the analysis of chromosome disorders for prenatal diagnosis. Chromosome banding techniques allow the evaluation of mitotic cells for structural and numerical aberrations and define the nature of any rearrangement.

  • With the advent of fluorescent in situ hybridization methodology, which combines the molecular technologies of chromosome-specific probes and in situ molecular hybridization, it has become possible to analyze chromosomal numerical and structural aberrations from interphase cells.
    • The use of molecular cytogenetic techniques should greatly increase the speed and diagnostic resolution of clinical specimens.

Molecular cytogenetic analyses have conferred substantial evidence with regards to the chromosomal architectures in cancer. Most importantly, the fluorescence in situ hybridization (FISH) technique that plays a leading role in diagnostic pathology for its single-cell analysis has provided crucial information regarding genomic variations in malignant cells.

  • Further development of molecular cytogenetic methodologies such as chromosome specific FISH karyotyping and comparative genomic hybridization have also helped in the detection of cryptic genetic changes in cancer.
    • But, the recent advancement of high throughput sequencing technologies has provided a more comprehensive genomic analyses resulting in novel chromosome rearrangements, somatic mutations as well as identification of fusion genes leading to new therapeutic targets.

The global market for molecular cytogenetics research report provides market size ($million 2017 to 2027), market share analysis, growth trends and forecast (CAGR%, 2021 to 2027).

The global market for molecular cytogenetics segmented by product (instruments, consumables, software & services), technology (fluorescence in situ hybridization, array-comparative genomic hybridization, others), application [cancer, personalized medicine, genetic disorders, others (neurological, cardiovascular and infectious diseases)], end user (hospitals, academic research institutes, clinical and research laboratories, pharmaceutical and biotechnology companies, others), and geography.

  • Based on the technologies, the array-comparative genomic hybridization (aCGH) segment accounted for the largest share of the total molecular cytogenetics market, and also expected to expand at the fastest double-digit growth rate during the next few years.
    • The aCGH is an advanced technique used to detect copy number variations at a higher resolution as compared to FISH technology. aCGH greatly improves the resolution and can identify chromosomal structural variation in a wide range of samples.
      • Moreover, aCGH technology does not require prior knowledge about DNA probes which are being used for analysis.
  • Among the applications, the oncology segment anticipated to expand at the fastest double-digit growth rate and contribute the largest share to the total market for molecular cytogenetics.
    • According to WHO, cancer is one of the leading causes of death and is estimated to account for 11.5 million deaths in 2030 worldwide. Lung cancer is one of the leading causes of death in both men and women.
      • Currently, there are many commercially available kits for cancer diagnosis out of which UroVysion bladder cancer kit of Abbott Molecular is the only kit available for early detection of bladder cancer.
        • Similarly, other detection kits such as PathVysion for breast cancer, Vysis CLL FISH probe kit for hematological disorders and others are also commercially available.

The global market for molecular cytogenetics research report is further segmented by geography into North America (U.S., Canada), Europe (U.K., Germany, France, Italy, Spain, Rest of EU), Asia Pacific (Japan, China, India, Rest of APAC), Latin America (Brazil, Mexico, Rest of LA), and Rest of the World.

  • In terms of geography, the North America region accounted for the largest share of the total molecular cytogenetics market, followed by Europe, mainly attributed to the presence of key players, well-established framework for the regulation of genetic tests, and rising incidence of various types of cancer in the region.
    • On the other hand, the Asia Pacific region anticipated to emerge as the fastest-growing regional market during the coming years.
      • The current trends and developments in human genetics and disease, raising public awareness, and availability and rapid adoption advanced diagnostics and therapies in the emerging countries are driving the Asian molecular cytogenetics market.

In addition, the global molecular cytogenetics market report provides the detailed market landscape (market drivers, restraints, opportunities), market attractiveness analysis, and market profitability analysis by key products and regions or countries. The report also tracks the major competitors operating in the global market by company overview, financial snapshot, major products, technologies, services offered and recent developments.

Major competitors operating in the global market for molecular cytogenetics and profiled in this report include Abbott Laboratories, Inc., Affymetrix, Inc., Agilent Technologies, Inc., Applied Spectral Imaging, Inc., Bio-Rad Laboratories, Inc., Cytognomix, Inc., CytoTest, Inc., Danaher Corporation, Illumina, Inc., Leica Microsystems GmbH, Oxford Gene Technology, PerkinElmer, Inc., Roche Holding AG (F. Hoffmann-La Roche AG), Sartorius AG (Biological Industries), SciGene Corporation, and Thermo Fisher Scientific, Inc. (Life Technologies Corp.).

  • Product
    • Instruments
    • Consumables (Kits & Reagents)
    • Software & Services
  • Technology
    • Fluorescence In Situ Hybridization (FISH)
    • Array-Comparative Genomic Hybridization (aCGH)
    • Others
  • Application
    • Cancer
    • Personalized Medicine
    • Genetic Disorders
    • Others (Neurological, Cardiovascular and Infectious Diseases)
  • End User
    • Hospitals
    • Academic Research Institutes
    • Clinical and Research Laboratories
    • Pharmaceutical and Biotechnology Companies
  • Geography
    • North America (U.S., Canada)
    • Europe (U.K., Germany, France, Italy, Spain, Rest of EU)
    • Asia Pacific (Japan, China, India, Rest of APAC)
    • Latin America (Brazil, Mexico, Rest of LA)
    • Rest of the World
  • Company Profiles
    • Abbott Laboratories, Inc.
    • Affymetrix, Inc.
    • Agilent Technologies, Inc.
    • Applied Spectral Imaging, Inc.
    • Bio-Rad Laboratories, Inc.
    • Cytognomix, Inc.
    • CytoTest, Inc.
    • Danaher Corporation
    • Illumina, Inc.
    • Leica Microsystems GmbH
    • Oxford Gene Technology
    • PerkinElmer, Inc.
    • Roche Holding AG (F. Hoffmann-La Roche AG)
    • Sartorius AG (Biological Industries)
    • SciGene Corporation
    • Thermo Fisher Scientific, Inc. (Life Technologies Corp.)

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