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Global Single Cell Analysis Market $6.7 Billion by 2027

The global market for single cell analysis anticipated to attain $6.7 billion by 2027, expanding at a double-digit CAGR of 13.8% over the forecast period, driven by increasing commercial availability of novel applications including multiomics and functional assays.

  • Other factors driving the market growth include rapid adoption of novel technologies in drug discovery, large-scale and well-funded research projects, availability of automated and high throughput systems.
Global Single Cell Analysis Market

In the field of cellular biology, single-cell analysis (SCA) studies the genomics, transcriptomics, proteomics, metabolomics and cell-cell interactions at the single cell level.

Single cell genome-wide approaches provide a valuable opportunity to measure different molecules, such as DNA, RNA, protein, and chromatin with ultimate resolution. Utilizing these different single cell omics profiling strategies as building blocks, we can construct a multi-omics profile for the same cell. Development of high-throughput next-generation sequencing technology has enabled multiomics analysis at single-cell resolution.

  • Single-cell multiomics would also enhance our understanding of the cellular properties and population architectures of heterogeneous tissues and provide snapshots of the interplay between these multiomics molecular layers and the complexity encompassing every level of biological organization.
    • Single-cell omics are becoming increasingly prevalent, owing to continuous technological improvements and they contribute to the discovery of new and rare cell types as well as deciphering of disease pathogenesis and outcome.
  • Single-cell omics have great potential in deciphering virus biology and virus-host cell interactions, and are a powerful tool in virology that should be applied more often in the future.

Single-cell analysis is the study of transcriptomic, genomics, metabolomics, and proteomics of a living being at a single-cell level. Single-cell analysis aids in measuring, analyzing, and sequencing the human genome at a single-cell heterogeneity.

  • The new technologies to isolate individual single cells from a complex sample and study the genomes and proteomes of single cells could provide great insights on genome variation and gene expression processes.
  • In clinical diagnostics, the single-cell analysis expected to standardize and automate workflows with valuable information for real-time monitoring of cancer and eventually new therapeutic strategies for the benefit of patients.
    • The key trends in the single-cell analysis market are the increasing number of collaborations, partnerships, and product launches.
      • The collaborations and partnerships majorly focus on new and innovative products, improving geographical presence, and purchasing single-cell analysis products.
  • For example, microfluidic-based single-cell sorting methods, high-throughput multiplexed quantitative PCR (qPCR) or sequencing approaches, mass cytometry-based proteomic strategies, and data analysis methods provided an unprecedented opportunity to identify rare cell types, such as cancer stem cells, and to investigate the dynamic processes of cell-fate transitions.

The global market for single cell analysis research report provides market size ($million 2017 to 2027), market share analysis, growth trends and forecast (CAGR%, 2021 to 2027).

The global market for single cell analysis segmented by cell type (animal cells, human cells, microbial cells), technology (flow cytometry, mass spectrometry, microscopy, next-generation sequencing polymerase chain reaction, others), product (instruments, reagents & kits, software & services), application (cancer, immunology, neurology, stem cells, others), end user (academic and research laboratories, biotechnology companies, hospitals and diagnostic laboratories, others), and geography.

  • In terms of cell types, the human cells segment accounted for the largest share of total single cell analysis (SCA) market, followed by the animal cells segment. The growing utilization of human cells in analysis anticipated to lead the growth of SCA market share reaching over 45% by the end of forecast period.
    • The recent development of novel technologies and methods for real-time single-cell analysis, in particular, the combination of fluorescent reporter dyes and strains, microfluidic and microelectromechanical systems, and time-lapse fluorescence microscopy offers tremendous and largely untapped potential for future exploration of the physiology of non-replicating cells.
  • Based on the technology, the next-generation sequencing (NGS) segment accounted for the largest share of the total single cell analysis market and also expected to witness the largest revenue share by the end of forecast period, attributed to its wider use in the detection of infectious microorganisms such as viruses and bacteria.
    • The NGS (covering both DNA and RNA sequencing) appears to be poised to address the majority of immuno-oncology biology and pathways, and its increasing prominence in tumor profiling in metastatic disease could position the technology as a front-runner in immuno-oncology diagnostics.
      • The maturation of single-cell RNA sequencing (scRNA-seq) technologies has coincided with transformative new methods to profile genetic, epigenetic, spatial, proteomic and lineage information in individual cells. 
      • In recent years, single-cell RNA sequencing (scRNA-seq) has significantly advanced our knowledge of biological systems. Single-cell RNA-seq has enabled gene expression to be studied at an unprecedented resolution. The promise of this technology is attracting a growing user base for single-cell analysis methods.
        • As more analysis tools are becoming available, it is becoming increasingly difficult to navigate this landscape and produce an up-to-date workflow to analyze the data. 
    • However, the high-parameter flow cytometry and polymerase chain reaction (PCR) technologies are anticipated to be important immuno-oncology diagnostic tools in the long run given their ability to detect expressed proteins at the single-cell level.
      • Although fluorescence activated cell sorting (FACS) has been widely used for isolation of highly purified cell populations, it has been reported that FACS can also be used to sort single cells.
        • Similarly, the magnetic-activated cell sorting (MACS), a passive separation technique to isolate different types of cells depending on their cluster of differentiation has been reported that MACS is capable of isolating specific cell populations with a purity >90% purification.
  • On the basis of applications, the cancer diagnostics segment accounted for the largest share of total single cell analysis market, followed by the autoimmune disease diagnostics segment.
    • Single-cell technology provides the means to detect rare cancer cells such as circulating tumor cells (CTCs) and cancer stem cells (CSCs), analyze intratumor heterogeneity (ITH), reveal the mechanism of tumor metastasis and investigate epigenetic alterations, and ultimately guide individualized treatment strategies.
      • Single-cell technology provides a powerful tool in detecting rare cancer cells, analyzing ITH, revealing epigenetic alterations, and developing individualized treatment strategies. The main aim now is to bring single-cell technology into clinical use; however, two main challenges remain.
        • Firstly, experimental time and costs are relatively high and need to be reduced to a reasonable level.
        • Secondly, more methods need to be developed to test paraffin-embedded samples, which is routine practice for keeping tissue specimens in the clinic.
      • These improvements will help to promote the clinical application of single-cell technology, which stands to benefit cancer diagnostics and treatment, and ultimately improve survival in cancer patients.
    • Recent advances in single-cell technologies have opened new avenues to characterize the intra-tumor cellular heterogeneity, identify rare cell types, measure mutation rates, and, ultimately, guide diagnosis and treatment.
      • The single-cell based methods have been developed to characterize the heterogeneity in seemingly homogenous cancer cell populations prior to and during treatment
  • By the end users, the academia and research laboratories segment accounted for the largest share of total single cell analysis market, followed by the hospitals and diagnostic laboratories segment.
  • Single-cell analysis technology is being widely employed in research settings.
    • The substantial number of ongoing research projects at universities that employ single-cell analysis assays have led to increased adoption of various single-cell analyses at research settings. The academic researchers are engaged in assessing spatial heterogeneity in gene expression profiles at a single cellular level.
      • Furthermore, single-cell transcriptomics is found to be useful for neuroscientists to understand cell types forming the brain.

The global market for single cell analysis research report is further segmented by geography into North America (U.S., Canada), Europe (U.K., Germany, France, Italy, Spain, Rest of EU), Asia Pacific (Japan, China, India, Rest of APAC), Latin America (Brazil, Mexico, Rest of LA), and Rest of the World.

  • In terms of geography, the North America followed by Europe regions led the global single cell analysis market, accounting for largest share of the total market.
    • Increasing government funding, rising personal healthcare expenditure, improved awareness, growing elderly people population, speedy adoption of novel analytical techniques, technological advancements, growing prevalence of diseases are some the key major factors driving the market growth in developed regions.
  • On the other hand, the Asia Pacific region expected to witness fastest growth rate, owing to high unmet needs, growing public awareness, improving healthcare infrastructure, presence of a large population base affected by infection diseases and chronic disorders, lower cost of products and tests, and increase in the investment by the major companies in the developing countries.

In addition, the global single cell analysis market report provides the detailed market landscape (market drivers, restraints, opportunities), market attractiveness analysis, and market profitability analysis by key products and regions or countries. The report also tracks the major competitors operating in the global market by company overview, financial snapshot, major products, technologies, services offered and recent developments.

Major competitors operating in the global market for single cell analysis and profiled in this report include Agilent Technologies, Inc., Becton, Dickinson and Company, Bio-Rad Laboratories, Inc., Danaher Corporation (Beckman Coulter Inc.), Fluidigm Corporation, Illumina, Inc., Merck & Co., Inc., Nanostring Technologies, Inc., Qiagen N.V., Takara Bio USA Holdings, Inc. (WaferGen Bio-systems, Inc.), and Thermo Fisher Scientific, Inc.

  • Cell Type
    • Animal Cells
    • Human Cells
    • Microbial Cells
  • Technology
    • Flow Cytometry
    • Mass Spectrometry
    • Microscopy
    • Next-Generation Sequencing
    • Polymerase Chain Reaction
    • Others
  • Product
    • Instruments
    • Reagents & Kits
    • Software & Services
  • Application
    • Cancer
    • Immunology
    • Neurology
    • Stem Cells
    • Others
  • End User
    • Academic and Research Laboratories
    • Biotechnology and Pharmaceutical Companies
    • Hospitals and Diagnostic Laboratories
    • Others (Cell Banks and IVF Centers)
  • Geography
    • North America (U.S., Canada)
    • Europe (U.K., Germany, France, Italy, Spain, Rest of EU)
    • Asia Pacific (Japan, China, India, Rest of APAC)
    • Latin America (Brazil, Mexico, Rest of LA)
    • Rest of the World
  • Company Profiles
    • Agilent Technologies, Inc.
    • Becton, Dickinson and Company
    • Bio-Rad Laboratories, Inc.
    • Danaher Corporation (Beckman Coulter Inc.)
    • Fluidigm Corporation
    • Illumina, Inc.
    • Merck & Co., Inc.
    • Nanostring Technologies, Inc.
    • Qiagen N.V.
    • Takara Bio USA Holdings, Inc. (WaferGen Bio-systems, Inc.)
    • Thermo Fisher Scientific, Inc.

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