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Global Knee Cartilage Repair Market $4.5 Billion by 2027

The global market for knee cartilage repair estimated to cross $4.5 billion by 2027, growing at a CAGR of 6.2% over the forecast period, as the increasing number of minimally invasive surgeries to repair, regenerate and replace cartilage are becoming more common.

  • The high prevalence of injury and lack of intrinsic tissue healing capacity leave a relatively young and healthy population on the path to degenerative osteoarthritis (OA) without intervention.
    • Knee osteoarthritis is an increasingly prevalent musculoskeletal disorder. OA is a major cause of disability and it is associated with rising rates of knee arthroplasties. (Osteo)chondral defects are a main risk factor for OA.
      • Increasing prevalence of bone and joint disorders and high demand for knee cartilage repair products are some of the other factors responsible for knee cartilage repair market growth.
Global Knee Cartilage Repair Market

Articular cartilage damage is an important, prevalent, and unsolved clinical issue following joint trauma or during osteoarthritis. Knee osteoarthritis is the most common form of arthritis, affecting millions of people around the world.

  • Untreated, it is usually a progressive degenerative disease in which the joint cartilage gradually wears away. Bone malalignment or being overweight can also contribute to damage. The diseases of osteoarthritis and inflammatory arthritis can directly damage the cartilage surfaces as well.
  • Diagnosis of cartilage damage will normally require and MRI or arthroscopy. Cartilage damage is often treated with non-steroidal anti-inflammatory drugs (NSAIDs).
    • Damage to knee cartilage can usually be confirmed with an MRI or X-rays, which are less expensive and time-consuming than an MRI. 
  • Some of the main knee cartilage repair procedures include lavage and debridement, marrow stimulation (microfracture), mosaicplasty, osteotomy, and joint replacement.
    • For focal full thickness cartilage defects at the knee, cartilage repair surgery represents an excellent therapeutic option, which aims to restore the cartilage tissue and function to prevent long-term OA.
      • Different cartilage repair procedures include microfracture, autologous matrix-induced chondrogenesis (AMIC), matrix-associated autologous chondrocyte implantation (MACI) and osteochondral autograft transfer system (OATS).
    • There are also a number of alternative surgical techniques or less common surgical procedures sometimes used to treat cartilage damage, including: allograft osteochondral transplantation (AOT), autologous chondrocyte implantation (ACI), and artificial scaffolds.
Knee Cartilage Repair Market

The global knee cartilage repair market report provides market size ($million 2017 to 2027), market volume (number of procedures), market share, growth trends and forecast (CAGR%, 2021 to 2027).

The global knee cartilage repair market segmented by procedure [chondrocyte implantation (autologous chondrocyte implantation, matrix-induced ACI, others), osteochondral grafts transplantation (osteochondral autograft transfer, osteochondral allograft transplantation, arthroscopic chondroplasty, partial knee replacement / partial knee arthroplasty, microfracture, others (meniscus repair), and geography.

  • The most common arthroscopic intervention for chondral injuries is chondroplasty, or removal of the loose pieces of cartilage.
    • Based on procedure type, the arthroscopic chondroplasty and partial knee replacement segments accounted for the largest share of the total market, owing to its easy availability and faster recovery time over other traditional methods of open knee surgeries.
      • An arthroscopic procedure performed to repair a small area of damage through smoothing of the articulate cartilage. This is only utilized in cases where there is mild-to-moderate cartilage wear.
    • However, the segments predicted to decline in market size over the coming years and replaced by other more efficient procedures such as the third generation matrix-induced autologous chondrocyte implantation (MACI), and other artificial allograft procedure segments in the near future.
      • The autologous chondrocyte implantation segment expected to grow at a highest rate during the forecast period, due to growing preference for the procedure, short turnaround time for patient recovery, and easy availability of the procedures.
        • More modern cartilage regeneration approaches include autologous chondrocyte implantation (ACI) and now MACI, as well as autologous matrix-induced chondrogenesis (AMIC).
          • The advantages of MACI procedure include simpler, less invasive procedure, significant reduction in surgical time, administration advantages, uniform distribution of cells, and improved post operative course, among others.
        • In recent years, to reduce the cost and the morbidity of autologous chondrocyte implantation and autologous chondrocyte implantation–related cartilage repair procedures, the so-called single stage techniques have been devised.
          • For example, Vericel offers its autologous cultured chondrocytes on porcine collagen membrane for knee cartilage repair.

The global market for knee cartilage repair research report is divided by geography into North America (U.S., Canada), Europe (U.K., Germany, France, Italy, Spain, Rest of EU), Asia Pacific (Japan, China, India, Rest of APAC), Latin America (Brazil, Mexico, Rest of LA), and Rest of the World.

  • In terms of geography, the North America region held the largest share of the global market and is anticipated to retain its dominance throughout the forecast period.
    • The increasing number of orthopedic procedures, introduction and rapid adoption of technologically advanced products, growing prevalence and incidence of bone & joint disorders and obesity, well-defined regulatory framework, and sophisticated healthcare infrastructure are the major factors driving the market growth in developed regions.
      • According to the CDC (Centers for Disease Control and Prevention), by 2040, an estimated 78 million (26%) US adults aged 18 years or older are projected to have doctor-diagnosed arthritis.
    • However, the Asia Pacific region anticipated to witness fastest growth rate, owing to high unmet needs, growing public awareness, improving healthcare spending, presence of a large population, lower cost of products, and increase in the investment by the major companies in the developing countries.

The global knee cartilage repair market report also provides the detailed market landscape (market drivers, restraints, opportunities), market attractiveness analysis and profiles of major competitors in the global market including company overview, financial snapshot, key products, technologies and services offered, and recent developments.

Major competitors operating in global knee cartilage repair market and included in the report are B. Braun Melsungen AG, , Histogenics Corporation, ISTO Biologics, Inc., Johnson & Johnson (DePuy Synthes), MEDIPOST Co., Ltd., Smith & Nephew plc (Osiris Therapeutics, Inc.), Stryker Corporation, Takeda Pharmaceutical Co. Ltd. (TiGenix N.V.), Vericel Corporation, and Zimmer Biomet.

  • Procedure
    • Chondrocyte Implantation
      • Autologous Chondrocyte Implantation (ACI)
      • Matrix-induced ACI (MACI)
      • Others (DeNovo NT Graft)
    • Osteochondral Grafts Transplantation
      • Osteochondral Autograft Transfer (OAT)
      • Osteochondral Allograft Transplantation (OCA)
    • Arthroscopic Chondroplasty
    • Partial Knee Replacement (PKR) / Partial Knee Arthroplasty (PKA)
    • Microfracture
    • Others (Meniscus Repair)
  • Geography
    • North America (U.S., Canada)
    • Europe (U.K., Germany, France, Italy, Spain, Rest of EU)
    • Asia Pacific (Japan, China, India, Rest of APAC)
    • Latin America (Brazil, Mexico, Rest of LA)
    • Rest of the World
  • Company Profiles
    • B. Braun Melsungen AG
    • Histogenics Corporation
    • ISTO Biologics, Inc.
    • Johnson & Johnson (DePuy Synthes)
    • MEDIPOST Co., Ltd.
    • Smith & Nephew plc (Osiris Therapeutics, Inc.)
    • Stryker Corporation
    • Takeda Pharmaceutical Co. Ltd. (TiGenix N.V.)
    • Vericel Corporation
    • Zimmer Biomet

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