Mammalian Cell Line Development Market by Process and Technology (Transfection and Selection, Single Cell Cloning Techniques – Manual Limited Dilution Technique, Fluorescence Activated Cell Sorter Technique, Clone Picking Technique, Other Techniques); Production Method (In-House, Outsource, Combined, Do-It-Yourself) and Forecast 2017-2021

Mammalian Cell Line Development Market by Process and Technology (Transfection and Selection, Single Cell Cloning Techniques – Manual Limited Dilution Technique, Fluorescence Activated Cell Sorter Technique, Clone Picking Technique, Other Techniques); Production Method (In-House, Outsource, Combined, Do-It-Yourself) and Forecast 2017-2021

Most biopharmaceutical companies use mammalian cell line development technologies for the production of biotherapeutic proteins. Protein therapeutics (including monoclonal antibodies [mAbs], peptides and recombinant proteins) represent the largest group of new products in development by the biopharmaceutical industry. These protein biologics are used for treating a multitude of conditions, such as, autoimmune disorders, hematologic disorders, hormonal dysregulation, cancers, infectious diseases and genetic disorders. Although most biotherapeutic proteins developed to date have been produced using the mammalian Chinese hamster ovary and murine myeloma (NS0, Sp2/0) cell lines, there has been a recent shift toward the use of human cell lines, such as human embryonic kidney 293 (HEK293) and fibrosarcoma HT-1080 cell lines. Mammalian expression systems are generally the preferred platform for manufacturing biopharmaceuticals, as these cell lines are able to produce large, complex proteins with post-translational modifications (PTMs; most notably glycosylation) similar to those produced in humans. Currently, mammalian cell line development technologies used by most biopharmaceutical companies are based on either the methotrexate (MTX) amplification technology or glutamine synthetase (GS) system. Single cell cloning or limiting dilution is then performed to ensure that the selected cells for further processing are producing the recombinant protein. In general, the mammalian cell line development process typically requires 6 to 12 months and is a time, capital and labor intensive process.

The global mammalian cell line development market segmentation is based on process and technology (transfection and selection, single cell cloning technique – manual limited dilution technique, fluorescence activated cell sorter technique, clone picking technique, others); production method (in-house, outsource, combined, do-it-yourself).

The global mammalian cell line development market research report provides market size (Revenue US$ Million 2014 to 2021), market share analysis, growth trends and forecast (CAGR%, 2017 to 2021). The global mammalian cell line development market research report is further segmented by geography into North America (U.S., Canada), Latin America (Brazil, Mexico, Rest of LA), Europe (U.K., Germany, France, Italy, Spain, Rest of EU), Asia Pacific (Japan, China, India, Rest of APAC), and Rest of the World. In addition, the global mammalian cell line development market report provides the detailed market landscape (market drivers, restraints, opportunities), market attractiveness analysis, and market profitability analysis by key products and regions or countries.  The report also tracks the major competitors operating in the global market by company overview, financial snapshot, major products, technologies, services offered and recent developments.

Major players operating in the global mammalian cell line development market and profiled in this report include Beckman Coulter, Becton Dickinson and Company, Boehringer Ingelheim, Catalent, Inc., CMC Biologics A/S, Lonza Group Ltd., Merck (EMD) Millipore, Partec (Sysmex Corporation), ProBioGen AG, Selexis SA, Sigma-Aldrich Co. LLC (SAFC), Sony Biotechnology, Inc., and Thermo Fisher Scientific, Inc.

Category:
  1. Introduction
  2. Executive Summary
    • Market Size Estimation (Revenue US$ Million, 2014-2021)
    • Forecast Estimation (Revenue US$ Million and CAGR%, 2017-2021)
  3. Research Methodology
  4. Market Landscape
    • Market Dynamics
      • Drivers
      • Barriers
      • Opportunities
    • Market Share Analysis
      • Companies
      • Products
    • Market Trends Analysis
      • Key success factors
      • Market Growth Rate
    • Market Attractiveness Analysis
    • Market Profitability Analysis
      • Buyer power
      • Supplier power
      • Barriers to entry
      • Threat of substitute products
      • Rivalry among firms in the industry
    • Distribution Channels
  5. Market Segmentation [refer Market Segments and Companies Tab]
    • Product Type (cells, media, serum, vaccine, protein, instrument, etc.)
    • Source Type
    • Reagents and Consumables Type
    • Diagnostic Test
    • Indication Type
    • Technology
    • Diagnostics, Therapeutic or Surgical Application
    • End User Groups
  6. Geography (Region, Country)
    • North America (U.S., Canada)
    • Europe (U.K., Germany, France, Italy, Spain, Rest of EU)
    • Latin America (Brazil, Mexico, Rest of LA)
    • Asia Pacific (Japan, China, India, Rest of APAC)
    • Rest of the World (Middle East & Africa)
  7. Company Profiles [refer Market Segments and Companies Tab]
    • Company Overview
    • Financial Snapshot (FY 2014-2016)
    • Product Portfolio
    • Business Strategies
    • Recent Developments
  8. Recommendations
  9. References

Mammalian Cell Line Development Market

1. Process and Technology
1.1. Transfection and Selection
1.2. Single Cell Cloning Techniques
1.2.1. Manual Limited Dilution Technique (CloneSelect)
1.2.2. Fluorescence Activated Cell Sorter (FACS) Technique
1.2.3. Clone Picking Technique (ClonePix)
1.2.4. Other Techniques (LEAP)

2. Production Method
2.1. In-House
2.2. Outsource
2.3. Combined
2.4. Do-It-Yourself (DIY)

3. Geography
3.1. North America (U.S., Canada)
3.2. Latin America (Brazil, Mexico, Rest of LA)
3.3. Europe (U.K., Germany, France, Italy, Spain, Rest of EU)
3.4. Asia Pacific (Japan, China, India, Rest of APAC
3.5. Rest of the World

4. Company Profiles
4.1. Beckman Coulter
4.2. Becton Dickinson and Company
4.3. Boehringer Ingelheim
4.4. Catalent, Inc.
4.5. CMC Biologics A/S
4.6. Lonza Group Ltd.
4.7. Merck (EMD) Millipore
4.8. Partec (Sysmex Corporation)
4.9. ProBioGen AG
4.10. Selexis SA
4.11. Sigma-Aldrich Co. LLC (SAFC)
4.12. Sony Biotechnology, Inc.
4.13. Thermo Fisher Scientific, Inc.

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